BRD-K94012289_OSI-027_MDAMB231_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K94012289_OSI-027_MDAMB231_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
ANGPT1 angiopoietin 1
ANXA4 annexin A4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BCAS3 breast carcinoma amplified sequence 3
C1S complement component 1, s subcomponent
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL10A1 collagen, type X, alpha 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FABP4 fatty acid binding protein 4, adipocyte
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRN granulin
HBP1 HMG-box transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGBP1 immunoglobulin (CD79A) binding protein 1
INHBA inhibin, beta A
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLHL24 kelch-like family member 24
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MT1X metallothionein 1X
MVP major vault protein
OSBPL9 oxysterol binding protein-like 9
PDGFRL platelet-derived growth factor receptor-like
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA1A phospholipase A1 member A
PLAT plasminogen activator, tissue
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RALGDS ral guanine nucleotide dissociation stimulator
RB1CC1 RB1-inducible coiled-coil 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SFRP4 secreted frizzled-related protein 4
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC16A6 solute carrier family 16, member 6
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
SSPN sarcospan
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TPP1 tripeptidyl peptidase I
TSPAN4 tetraspanin 4
VAT1 vesicle amine transport 1
VNN1 vanin 1
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AK2 adenylate kinase 2
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCR2 chemokine (C-C motif) receptor 2
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CENPU centromere protein U
CTPS1 CTP synthase 1
CTSC cathepsin C
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HAT1 histone acetyltransferase 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA14 heat shock 70kDa protein 14
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF20A kinesin family member 20A
KRT4 keratin 4, type II
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MEX3D mex-3 RNA binding family member D
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RACGAP1 Rac GTPase activating protein 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SHB Src homology 2 domain containing adaptor protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
TGFBI transforming growth factor, beta-induced, 68kDa
TMPO thymopoietin
TNC tenascin C
TPI1 triosephosphate isomerase 1
ZWINT ZW10 interacting kinetochore protein