BRD-K94012289_OSI-027_MCF7_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K94012289_OSI-027_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BIRC3 baculoviral IAP repeat containing 3
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HMGB2 high mobility group box 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
LTBP3 latent transforming growth factor beta binding protein 3
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYOF myoferlin
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NTS neurotensin
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SYBU syntabulin (syntaxin-interacting)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
CAST calpastatin
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CKAP4 cytoskeleton-associated protein 4
CLIC3 chloride intracellular channel 3
EMX2 empty spiracles homeobox 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAS Fas cell surface death receptor
FGFR3 fibroblast growth factor receptor 3
HBB hemoglobin, beta
HEBP2 heme binding protein 2
HSPA1A heat shock 70kDa protein 1A
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCP4 Purkinje cell protein 4
RGS4 regulator of G-protein signaling 4
TDO2 tryptophan 2,3-dioxygenase
TGFA transforming growth factor, alpha
TXN thioredoxin