BRD-K94012289_OSI-027_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K94012289_OSI-027_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK14 cyclin-dependent kinase 14
DKK3 dickkopf WNT signaling pathway inhibitor 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FBN2 fibrillin 2
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
GRN granulin
H1FX H1 histone family, member X
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JUND jun D proto-oncogene
KYNU kynureninase
LETMD1 LETM1 domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP1 matrix metallopeptidase 1
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBR1 neighbor of BRCA1 gene 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
RALGDS ral guanine nucleotide dissociation stimulator
RIN2 Ras and Rab interactor 2
RPL31 ribosomal protein L31
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC22A18 solute carrier family 22, member 18
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNS3 tensin 3
TSPAN31 tetraspanin 31
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
ATAD2 ATPase family, AAA domain containing 2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPN centromere protein N
COTL1 coactosin-like F-actin binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEF8 differentially expressed in FDCP 8 homolog (mouse)
DHCR7 7-dehydrocholesterol reductase
DNM1L dynamin 1-like
EBP emopamil binding protein (sterol isomerase)
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
GALE UDP-galactose-4-epimerase
GAS2L1 growth arrest-specific 2 like 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MGP matrix Gla protein
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
PPIF peptidylprolyl isomerase F
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SLPI secretory leukocyte peptidase inhibitor
STK17A serine/threonine kinase 17a
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1