BRD-K94012289_OSI-027_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K94012289_OSI-027_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ADGRG6 adhesion G protein-coupled receptor G6
AKAP9 A kinase (PRKA) anchor protein 9
AMDHD2 amidohydrolase domain containing 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
DAAM1 dishevelled associated activator of morphogenesis 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSP desmoplakin
EGFR epidermal growth factor receptor
FN1 fibronectin 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPX3 glutathione peroxidase 3
GRB7 growth factor receptor-bound protein 7
GSN gelsolin
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KLHDC2 kelch domain containing 2
KRT15 keratin 15, type I
METTL7A methyltransferase like 7A
MTUS1 microtubule associated tumor suppressor 1
MYOF myoferlin
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RND3 Rho family GTPase 3
SFRP1 secreted frizzled-related protein 1
SKAP2 src kinase associated phosphoprotein 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNM synemin, intermediate filament protein
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
ATF5 activating transcription factor 5
C8ORF33 chromosome 8 open reading frame 33
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
DACH1 dachshund family transcription factor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EREG epiregulin
FASTKD5 FAST kinase domains 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HSPA1A heat shock 70kDa protein 1A
IL17RB interleukin 17 receptor B
JMJD6 jumonji domain containing 6
KCTD14 potassium channel tetramerization domain containing 14
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKSL1 MARCKS-like 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOP56 NOP56 ribonucleoprotein
NXT1 nuclear transport factor 2-like export factor 1
PAH phenylalanine hydroxylase
PPIF peptidylprolyl isomerase F
PSAT1 phosphoserine aminotransferase 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFPQ splicing factor proline/glutamine-rich
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TF transferrin
THY1 Thy-1 cell surface antigen
TXNDC9 thioredoxin domain containing 9