BRD-K94012289_OSI-027_MCF10A_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K94012289_OSI-027_MCF10A_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CERS6 ceramide synthase 6
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
COL4A6 collagen, type IV, alpha 6
CREB1 cAMP responsive element binding protein 1
CXADR coxsackie virus and adenovirus receptor
CYTH1 cytohesin 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HMGA1 high mobility group AT-hook 1
IGFBP6 insulin-like growth factor binding protein 6
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LAMB3 laminin, beta 3
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NUMA1 nuclear mitotic apparatus protein 1
OLFM1 olfactomedin 1
PFKL phosphofructokinase, liver
PLXNB2 plexin B2
PNMA2 paraneoplastic Ma antigen 2
PPAP2C phosphatidic acid phosphatase type 2C
PSAP prosaposin
SFRP1 secreted frizzled-related protein 1
SKAP2 src kinase associated phosphoprotein 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1C3 aldo-keto reductase family 1, member C3
APOC1 apolipoprotein C-I
APOE apolipoprotein E
CCL4 chemokine (C-C motif) ligand 4
CDC25A cell division cycle 25A
CHD7 chromodomain helicase DNA binding protein 7
COG2 component of oligomeric golgi complex 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EGR2 early growth response 2
ESR1 estrogen receptor 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
JMJD6 jumonji domain containing 6
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
MCAM melanoma cell adhesion molecule
MMP9 matrix metallopeptidase 9
MUC4 mucin 4, cell surface associated
MXRA7 matrix-remodelling associated 7
MYRF myelin regulatory factor
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEB nebulin
NR2F2 nuclear receptor subfamily 2, group F, member 2
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PRPF4 pre-mRNA processing factor 4
RAP2C RAP2C, member of RAS oncogene family
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPAG4 sperm associated antigen 4
TNNC1 troponin C type 1 (slow)
WT1 Wilms tumor 1
XBP1 X-box binding protein 1