BRD-K94012289_OSI-027_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

308 genes differentially expressed following the BRD-K94012289_OSI-027_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ANXA5 annexin A5
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX1 armadillo repeat containing, X-linked 1
ASMTL acetylserotonin O-methyltransferase-like
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CFLAR CASP8 and FADD-like apoptosis regulator
CIRBP cold inducible RNA binding protein
CLIC5 chloride intracellular channel 5
COL6A1 collagen, type VI, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTSA cathepsin A
CTSB cathepsin B
CTSD cathepsin D
DCN decorin
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNASE1L1 deoxyribonuclease I-like 1
DUSP4 dual specificity phosphatase 4
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHD2 EH-domain containing 2
EPAS1 endothelial PAS domain protein 1
FAM114A1 family with sequence similarity 114, member A1
FAM127A family with sequence similarity 127, member A
FAM134A family with sequence similarity 134, member A
FAM50A family with sequence similarity 50, member A
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FZD7 frizzled class receptor 7
GAA glucosidase, alpha; acid
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GDI1 GDP dissociation inhibitor 1
GLRX glutaredoxin (thioltransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GRN granulin
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMGA2 high mobility group AT-hook 2
HS1BP3 HCLS1 binding protein 3
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2R insulin-like growth factor 2 receptor
IRS1 insulin receptor substrate 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF2 Kruppel-like factor 2
LAMB2 laminin, beta 2 (laminin S)
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP2 latent transforming growth factor beta binding protein 2
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLPH melanophilin
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MYO6 myosin VI
NCOR2 nuclear receptor corepressor 2
NDRG1 N-myc downstream regulated 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOTCH2NL notch 2 N-terminal like
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSMR oncostatin M receptor
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PGLS 6-phosphogluconolactonase
PHYH phytanoyl-CoA 2-hydroxylase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPL periplakin
PRAF2 PRA1 domain family, member 2
PROS1 protein S (alpha)
PTX3 pentraxin 3, long
RPS27L ribosomal protein S27-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFXN3 sideroflexin 3
SLC22A18 solute carrier family 22, member 18
SOD2 superoxide dismutase 2, mitochondrial
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
SULF1 sulfatase 1
SYT17 synaptotagmin XVII
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM59 transmembrane protein 59
TMSB15A thymosin beta 15a
TNIP1 TNFAIP3 interacting protein 1
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
VSIG4 V-set and immunoglobulin domain containing 4
WDR13 WD repeat domain 13
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DHFR dihydrofolate reductase
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBP1 guanylate binding protein 1, interferon-inducible
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA14 heat shock 70kDa protein 14
HSPA4 heat shock 70kDa protein 4
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MOCS2 molybdenum cofactor synthesis 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC1 NDC1 transmembrane nucleoporin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NUP107 nucleoporin 107kDa
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
NXT1 nuclear transport factor 2-like export factor 1
OIP5 Opa interacting protein 5
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
RACGAP1 Rac GTPase activating protein 1
RAD9A RAD9 homolog A (S. pombe)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA2 replication protein A2, 32kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPHS1 selenophosphate synthetase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein