BRD-K94012289_OSI-027_MCF10A_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-K94012289_OSI-027_MCF10A_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTC1 actin, alpha, cardiac muscle 1
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA5 annexin A5
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP9A ATPase, class II, type 9A
BHLHE41 basic helix-loop-helix family, member e41
BMP4 bone morphogenetic protein 4
CCDC176 coiled-coil domain containing 176
CCNG2 cyclin G2
CES1 carboxylesterase 1
CFB complement factor B
CHRDL1 chordin-like 1
CIB1 calcium and integrin binding 1 (calmyrin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COCH cochlin
CRABP1 cellular retinoic acid binding protein 1
CREBL2 cAMP responsive element binding protein-like 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSB cathepsin B
CXCR4 chemokine (C-X-C motif) receptor 4
DDAH2 dimethylarginine dimethylaminohydrolase 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM50A family with sequence similarity 50, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FSTL1 follistatin-like 1
FXYD5 FXYD domain containing ion transport regulator 5
FZD1 frizzled class receptor 1
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GPR137B G protein-coupled receptor 137B
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GSN gelsolin
HBP1 HMG-box transcription factor 1
HLA-E major histocompatibility complex, class I, E
IDS iduronate 2-sulfatase
IFNAR1 interferon (alpha, beta and omega) receptor 1
INHBA inhibin, beta A
ITGB4 integrin, beta 4
KDM3A lysine (K)-specific demethylase 3A
KLHL9 kelch-like family member 9
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMC2 laminin, gamma 2
LEPROT leptin receptor overlapping transcript
LGALS1 lectin, galactoside-binding, soluble, 1
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MFGE8 milk fat globule-EGF factor 8 protein
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
MT1M metallothionein 1M
MTMR11 myotubularin related protein 11
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
MZT2A mitotic spindle organizing protein 2A
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFC platelet derived growth factor C
PECAM1 platelet/endothelial cell adhesion molecule 1
PEX11A peroxisomal biogenesis factor 11 alpha
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PLIN1 perilipin 1
PLXNB2 plexin B2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPL periplakin
PROM1 prominin 1
PSCA prostate stem cell antigen
PTK2B protein tyrosine kinase 2 beta
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RBPMS RNA binding protein with multiple splicing
RGS5 regulator of G-protein signaling 5
RRAS related RAS viral (r-ras) oncogene homolog
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT10 septin 10
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A18 solute carrier family 22, member 18
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC35G2 solute carrier family 35, member G2
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSPN sarcospan
STC1 stanniocalcin 1
SYT17 synaptotagmin XVII
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM2 transglutaminase 2
TIMP2 TIMP metallopeptidase inhibitor 2
TLE4 transducin-like enhancer of split 4
TMOD1 tropomodulin 1
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TPBG trophoblast glycoprotein
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
C4BPA complement component 4 binding protein, alpha
CAB39 calcium binding protein 39
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A1 collagen, type I, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GARS glycyl-tRNA synthetase
GGCT gamma-glutamylcyclotransferase
H2AFZ H2A histone family, member Z
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGB2 high mobility group box 2
HSPA8 heat shock 70kDa protein 8
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
NDP Norrie disease (pseudoglioma)
NOP56 NOP56 ribonucleoprotein
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PSAT1 phosphoserine aminotransferase 1
PSRC1 proline/serine-rich coiled-coil 1
RAD51C RAD51 paralog C
RAD9A RAD9 homolog A (S. pombe)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
TARP TCR gamma alternate reading frame protein
TESC tescalcin
TMEM97 transmembrane protein 97
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)