BRD-K94012289_OSI-027_MCF10A_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K94012289_OSI-027_MCF10A_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
AMOTL2 angiomotin like 2
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA1 cyclin A1
CCNG2 cyclin G2
CD9 CD9 molecule
CHRDL1 chordin-like 1
COCH cochlin
CRABP2 cellular retinoic acid binding protein 2
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAXDC2 fatty acid hydroxylase domain containing 2
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FN1 fibronectin 1
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GDI1 GDP dissociation inhibitor 1
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
GPX4 glutathione peroxidase 4
GRN granulin
GYPC glycophorin C (Gerbich blood group)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HLA-E major histocompatibility complex, class I, E
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
KCTD12 potassium channel tetramerization domain containing 12
KDM3A lysine (K)-specific demethylase 3A
KIF2C kinesin family member 2C
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP3 latent transforming growth factor beta binding protein 3
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MCAM melanoma cell adhesion molecule
MET MET proto-oncogene, receptor tyrosine kinase
MLPH melanophilin
MME membrane metallo-endopeptidase
MN1 meningioma (disrupted in balanced translocation) 1
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PLIN1 perilipin 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RGS5 regulator of G-protein signaling 5
SDC4 syndecan 4
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
SSPN sarcospan
TACSTD2 tumor-associated calcium signal transducer 2
TANK TRAF family member-associated NFKB activator
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1
VCAN versican
VEGFC vascular endothelial growth factor C
WASF3 WAS protein family, member 3
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
AURKA aurora kinase A
CD320 CD320 molecule
CDC25A cell division cycle 25A
CKS2 CDC28 protein kinase regulatory subunit 2
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
FASTKD5 FAST kinase domains 5
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GAL galanin/GMAP prepropeptide
GNAS GNAS complex locus
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44 interferon-induced protein 44
IL1R2 interleukin 1 receptor, type II
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NOP16 NOP16 nucleolar protein
PARP2 poly (ADP-ribose) polymerase 2
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PRPF4 pre-mRNA processing factor 4
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
TFF3 trefoil factor 3 (intestinal)
TMEM70 transmembrane protein 70
TXN thioredoxin
VSNL1 visinin-like 1