BRD-K94012289_OSI-027_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K94012289_OSI-027_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADCK3 aarF domain containing kinase 3
AHNAK AHNAK nucleoprotein
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
AXIN1 axin 1
C1ORF115 chromosome 1 open reading frame 115
CAMLG calcium modulating ligand
CCL13 chemokine (C-C motif) ligand 13
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD209 CD209 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP68 centrosomal protein 68kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CRABP1 cellular retinoic acid binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSF cathepsin F
CXCL14 chemokine (C-X-C motif) ligand 14
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DEPTOR DEP domain containing MTOR-interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EIF3D eukaryotic translation initiation factor 3, subunit D
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FN1 fibronectin 1
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
IPO13 importin 13
IRS2 insulin receptor substrate 2
KRT23 keratin 23, type I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MMP1 matrix metallopeptidase 1
NPDC1 neural proliferation, differentiation and control, 1
OLFM4 olfactomedin 4
PDGFC platelet derived growth factor C
PROM1 prominin 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCD5 stearoyl-CoA desaturase 5
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SPINK1 serine peptidase inhibitor, Kazal type 1
SRRM2 serine/arginine repetitive matrix 2
TCTN1 tectonic family member 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF4 transmembrane 4 L six family member 4
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ADM adrenomedullin
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QBP complement component 1, q subcomponent binding protein
CCND3 cyclin D3
CDC6 cell division cycle 6
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L2 chitinase 3-like 2
CLU clusterin
CTSZ cathepsin Z
DCXR dicarbonyl/L-xylulose reductase
DDIT4 DNA-damage-inducible transcript 4
DOCK10 dedicator of cytokinesis 10
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FRZB frizzled-related protein
GBP1 guanylate binding protein 1, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GFOD1 glucose-fructose oxidoreductase domain containing 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IPW imprinted in Prader-Willi syndrome (non-protein coding)
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KRT5 keratin 5, type II
L1CAM L1 cell adhesion molecule
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
PCNA proliferating cell nuclear antigen
PDIA3 protein disulfide isomerase family A, member 3
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTK2 protein tyrosine kinase 2
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX10 sorting nexin 10
SPATS2L spermatogenesis associated, serine-rich 2-like
SPP1 secreted phosphoprotein 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TUBG1 tubulin, gamma 1
TXN thioredoxin
TYMS thymidylate synthetase
WARS tryptophanyl-tRNA synthetase
WFDC2 WAP four-disulfide core domain 2