BRD-K94012289_OSI-027_HME1_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K94012289_OSI-027_HME1_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
CCK cholecystokinin
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
COMP cartilage oligomeric matrix protein
CST3 cystatin C
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
ICAM1 intercellular adhesion molecule 1
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
ITM2A integral membrane protein 2A
JUND jun D proto-oncogene
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MARCKSL1 MARCKS-like 1
MLF1 myeloid leukemia factor 1
OPN3 opsin 3
PDGFD platelet derived growth factor D
PLXNB2 plexin B2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RBP1 retinol binding protein 1, cellular
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SSBP2 single-stranded DNA binding protein 2
TES testin LIM domain protein
TPPP3 tubulin polymerization-promoting protein family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB6 tubulin, beta 6 class V
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ASS1 argininosuccinate synthase 1
CA12 carbonic anhydrase XII
CBX1 chromobox homolog 1
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
DDIT4 DNA-damage-inducible transcript 4
DLG5 discs, large homolog 5 (Drosophila)
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
LEF1 lymphoid enhancer-binding factor 1
MPZL2 myelin protein zero-like 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
PI3 peptidase inhibitor 3, skin-derived
PLS1 plastin 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SIRT3 sirtuin 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
STC2 stanniocalcin 2
STK39 serine threonine kinase 39
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TXNDC9 thioredoxin domain containing 9
TYRP1 tyrosinase-related protein 1