BRD-K94012289_OSI-027_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K94012289_OSI-027_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
ANXA4 annexin A4
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CREBL2 cAMP responsive element binding protein-like 2
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CTSK cathepsin K
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF3G eukaryotic translation initiation factor 3, subunit G
ERBB2 erb-b2 receptor tyrosine kinase 2
ETHE1 ethylmalonic encephalopathy 1
FAM60A family with sequence similarity 60, member A
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
HDAC9 histone deacetylase 9
HIST3H2A histone cluster 3, H2a
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIMS1 LIM and senescent cell antigen-like domains 1
LMOD1 leiomodin 1 (smooth muscle)
LXN latexin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MTSS1 metastasis suppressor 1
NBR1 neighbor of BRCA1 gene 1
NPC1 Niemann-Pick disease, type C1
PDGFD platelet derived growth factor D
PELI2 pellino E3 ubiquitin protein ligase family member 2
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PTCH1 patched 1
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAP1GAP2 RAP1 GTPase activating protein 2
REG1A regenerating islet-derived 1 alpha
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC1 serine incorporator 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP4 secreted frizzled-related protein 4
SOD2 superoxide dismutase 2, mitochondrial
SPG11 spastic paraplegia 11 (autosomal recessive)
SQSTM1 sequestosome 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI2 tissue factor pathway inhibitor 2
TNS3 tensin 3
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
VAT1 vesicle amine transport 1
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZNF277 zinc finger protein 277
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALR calreticulin
CCNA2 cyclin A2
CCNF cyclin F
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CIT citron rho-interacting serine/threonine kinase
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
ELAVL1 ELAV like RNA binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EMP2 epithelial membrane protein 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT23 keratin 23, type I
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
RACGAP1 Rac GTPase activating protein 1
RCC1 regulator of chromosome condensation 1
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPTSSA serine palmitoyltransferase, small subunit A
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN2 transgelin 2
TBL1X transducin (beta)-like 1X-linked
TIMELESS timeless circadian clock
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNC13B unc-13 homolog B (C. elegans)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein