BRD-K94012289_OSI-027_HME1_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K94012289_OSI-027_HME1_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD36B ankyrin repeat domain 36B
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ATP8B4 ATPase, class I, type 8B, member 4
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
CNN1 calponin 1, basic, smooth muscle
CTGF connective tissue growth factor
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DMD dystrophin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4B eukaryotic translation initiation factor 4B
ETHE1 ethylmalonic encephalopathy 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBLN1 fibulin 1
FXR1 fragile X mental retardation, autosomal homolog 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRN granulin
GSN gelsolin
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDAC9 histone deacetylase 9
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1B interleukin 1, beta
JAG1 jagged 1
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS3 lectin, galactoside-binding, soluble, 3
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MTA1 metastasis associated 1
NAP1L1 nucleosome assembly protein 1-like 1
NCF2 neutrophil cytosolic factor 2
OLFM4 olfactomedin 4
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RBKS ribokinase
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RPL31 ribosomal protein L31
SDC4 syndecan 4
SERINC1 serine incorporator 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
SSPN sarcospan
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
VCAN versican
VNN1 vanin 1
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARPC5L actin related protein 2/3 complex, subunit 5-like
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QA complement component 1, q subcomponent, A chain
C20ORF24 chromosome 20 open reading frame 24
CALR calreticulin
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBP emopamil binding protein (sterol isomerase)
EMP2 epithelial membrane protein 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXM1 forkhead box M1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GTSE1 G-2 and S-phase expressed 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LMNB1 lamin B1
LYPD1 LY6/PLAUR domain containing 1
MELK maternal embryonic leucine zipper kinase
MLEC malectin
MSMO1 methylsterol monooxygenase 1
NCAPG non-SMC condensin I complex, subunit G
NET1 neuroepithelial cell transforming 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PTTG1 pituitary tumor-transforming 1
RAD51C RAD51 paralog C
RGS1 regulator of G-protein signaling 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SDF2L1 stromal cell-derived factor 2-like 1
SPAG5 sperm associated antigen 5
SPINK5 serine peptidase inhibitor, Kazal type 5
SQLE squalene epoxidase
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein