BRD-K94012289_OSI-027_HME1_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K94012289_OSI-027_HME1_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADGRG6 adhesion G protein-coupled receptor G6
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA4 annexin A4
AXL AXL receptor tyrosine kinase
BHLHE41 basic helix-loop-helix family, member e41
BPGM 2,3-bisphosphoglycerate mutase
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CREBL2 cAMP responsive element binding protein-like 2
CST1 cystatin SN
CTSF cathepsin F
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DSE dermatan sulfate epimerase
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FGFR1 fibroblast growth factor receptor 1
GOLGA8B golgin A8 family, member B
GPR137B G protein-coupled receptor 137B
GRN granulin
HBP1 HMG-box transcription factor 1
HMGA2 high mobility group AT-hook 2
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LINC00342 long intergenic non-protein coding RNA 342
LTA4H leukotriene A4 hydrolase
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MTA1 metastasis associated 1
NAP1L1 nucleosome assembly protein 1-like 1
NPDC1 neural proliferation, differentiation and control, 1
OLFM4 olfactomedin 4
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLSCR3 phospholipid scramblase 3
PTHLH parathyroid hormone-like hormone
QARS glutaminyl-tRNA synthetase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS10 regulator of G-protein signaling 10
RNASET2 ribonuclease T2
SALL1 spalt-like transcription factor 1
SLPI secretory leukocyte peptidase inhibitor
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SSPN sarcospan
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TGFB2 transforming growth factor, beta 2
TPM1 tropomyosin 1 (alpha)
TUBA1A tubulin, alpha 1a
TUBB2B tubulin, beta 2B class IIb
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CDC42 cell division cycle 42
CDKN3 cyclin-dependent kinase inhibitor 3
CKS1B CDC28 protein kinase regulatory subunit 1B
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FABP4 fatty acid binding protein 4, adipocyte
FASTKD3 FAST kinase domains 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GATA3 GATA binding protein 3
GPX3 glutathione peroxidase 3
HAT1 histone acetyltransferase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MSMO1 methylsterol monooxygenase 1
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PBK PDZ binding kinase
PCSK6 proprotein convertase subtilisin/kexin type 6
RAD51C RAD51 paralog C
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMELESS timeless circadian clock
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TWF1 twinfilin actin binding protein 1
UBE2S ubiquitin-conjugating enzyme E2S