BRD-K94012289_OSI-027_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K94012289_OSI-027_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AXL AXL receptor tyrosine kinase
BBX bobby sox homolog (Drosophila)
BHLHE41 basic helix-loop-helix family, member e41
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CLEC2B C-type lectin domain family 2, member B
CST1 cystatin SN
CTGF connective tissue growth factor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DARS aspartyl-tRNA synthetase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DST dystonin
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8 epidermal growth factor receptor pathway substrate 8
ETV5 ets variant 5
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCTD12 potassium channel tetramerization domain containing 12
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MEF2C myocyte enhancer factor 2C
MSN moesin
MVP major vault protein
MXRA8 matrix-remodelling associated 8
NPDC1 neural proliferation, differentiation and control, 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PDLIM5 PDZ and LIM domain 5
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RSRP1 arginine/serine-rich protein 1
SAMD4A sterile alpha motif domain containing 4A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC22A18 solute carrier family 22, member 18
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
SYNJ2 synaptojanin 2
TACC1 transforming, acidic coiled-coil containing protein 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRIM44 tripartite motif containing 44
TRIM8 tripartite motif containing 8
VCAN versican
VCL vinculin
VNN1 vanin 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AIM1 absent in melanoma 1
ALOX5 arachidonate 5-lipoxygenase
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPU centromere protein U
CETN2 centrin, EF-hand protein, 2
CHEK2 checkpoint kinase 2
CHL1 cell adhesion molecule L1-like
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLU clusterin
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSDL2 hydroxysteroid dehydrogenase like 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
LMNB1 lamin B1
LPL lipoprotein lipase
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MPO myeloperoxidase
MREG melanoregulin
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
OIP5 Opa interacting protein 5
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOH ras homolog family member H
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
TDO2 tryptophan 2,3-dioxygenase
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
ZWINT ZW10 interacting kinetochore protein