BRD-K94012289_OSI-027_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K94012289_OSI-027_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AOX1 aldehyde oxidase 1
BBX bobby sox homolog (Drosophila)
BHLHE41 basic helix-loop-helix family, member e41
CD14 CD14 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHGB chromogranin B
CP ceruloplasmin (ferroxidase)
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ERBB3 erb-b2 receptor tyrosine kinase 3
F5 coagulation factor V (proaccelerin, labile factor)
FNDC3B fibronectin type III domain containing 3B
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
GOLGA8A golgin A8 family, member A
IGFBP1 insulin-like growth factor binding protein 1
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
KLF9 Kruppel-like factor 9
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MAST4 microtubule associated serine/threonine kinase family member 4
MGLL monoglyceride lipase
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MVP major vault protein
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHACTR2 phosphatase and actin regulator 2
RBP4 retinol binding protein 4, plasma
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SLC22A18 solute carrier family 22, member 18
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SYNJ2 synaptojanin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TMC5 transmembrane channel-like 5
TRIM44 tripartite motif containing 44

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANXA2 annexin A2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
EREG epiregulin
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT13 keratin 13, type I
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MDK midkine (neurite growth-promoting factor 2)
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SPC25 SPC25, NDC80 kinetochore complex component
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein