BRD-K94012289_OSI-027_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

160 genes differentially expressed following the BRD-K94012289_OSI-027_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD2 abhydrolase domain containing 2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AXL AXL receptor tyrosine kinase
BBX bobby sox homolog (Drosophila)
BHLHE41 basic helix-loop-helix family, member e41
CD9 CD9 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COL10A1 collagen, type X, alpha 1
CST1 cystatin SN
CST4 cystatin S
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DST dystonin
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
INHBB inhibin, beta B
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MMP7 matrix metallopeptidase 7
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MVP major vault protein
NAV2 neuron navigator 2
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1D2 nuclear receptor subfamily 1, group D, member 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PTPRE protein tyrosine phosphatase, receptor type, E
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
S100A11 S100 calcium binding protein A11
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TPM1 tropomyosin 1 (alpha)
TRIM8 tripartite motif containing 8
TXNIP thioredoxin interacting protein
VCAN versican
VCL vinculin
ZYX zyxin

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
AK4 adenylate kinase 4
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BIRC5 baculoviral IAP repeat containing 5
C1S complement component 1, s subcomponent
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC6 cell division cycle 6
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CKB creatine kinase, brain
CLU clusterin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
ELANE elastase, neutrophil expressed
ELP5 elongator acetyltransferase complex subunit 5
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FGFR4 fibroblast growth factor receptor 4
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTA1 glutathione S-transferase alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
LTF lactotransferrin
LYZ lysozyme
MREG melanoregulin
OIP5 Opa interacting protein 5
PBX1 pre-B-cell leukemia homeobox 1
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCH protein kinase C, eta
PSAT1 phosphoserine aminotransferase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RHOH ras homolog family member H
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIAH2 siah E3 ubiquitin protein ligase 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SMAD1 SMAD family member 1
STC2 stanniocalcin 2
TFRC transferrin receptor
TMEM47 transmembrane protein 47
TSPAN7 tetraspanin 7
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)