BRD-K94012289_OSI-027_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K94012289_OSI-027_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR1 activin A receptor, type I
ADAM9 ADAM metallopeptidase domain 9
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BBX bobby sox homolog (Drosophila)
BTG3 BTG family, member 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CLDN3 claudin 3
COL11A1 collagen, type XI, alpha 1
CPM carboxypeptidase M
CST1 cystatin SN
CTGF connective tissue growth factor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DKK4 dickkopf WNT signaling pathway inhibitor 4
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA3 EPH receptor A3
EYA1 EYA transcriptional coactivator and phosphatase 1
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAGE3 G antigen 3
GALC galactosylceramidase
GPR137B G protein-coupled receptor 137B
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HOPX HOP homeobox
HOXB7 homeobox B7
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KIZ kizuna centrosomal protein
KLF9 Kruppel-like factor 9
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LEPROT leptin receptor overlapping transcript
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MITF microphthalmia-associated transcription factor
MLPH melanophilin
MT1H metallothionein 1H
MVP major vault protein
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB4 phospholipase C, beta 4
PRAME preferentially expressed antigen in melanoma
PRNP prion protein
RGS16 regulator of G-protein signaling 16
RPL39L ribosomal protein L39-like
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFN stratifin
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC22A18 solute carrier family 22, member 18
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
VIM vimentin

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ANXA6 annexin A6
ASS1 argininosuccinate synthase 1
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CLC Charcot-Leyden crystal galectin
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
ELN elastin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRWD1 glutamate-rich WD repeat containing 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HRSP12 heat-responsive protein 12
HSDL2 hydroxysteroid dehydrogenase like 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
KAZN kazrin, periplakin interacting protein
LMNB1 lamin B1
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MYLK myosin light chain kinase
NCK1 NCK adaptor protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRCAM neuronal cell adhesion molecule
PHGDH phosphoglycerate dehydrogenase
PMM2 phosphomannomutase 2
PTN pleiotrophin
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPIA ribose 5-phosphate isomerase A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SYBU syntabulin (syntaxin-interacting)
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase