BRD-K94012289_OSI-027_HEPG2_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K94012289_OSI-027_HEPG2_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRE5 adhesion G protein-coupled receptor E5
BCL2A1 BCL2-related protein A1
BID BH3 interacting domain death agonist
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL1A1 collagen, type I, alpha 1
COL6A3 collagen, type VI, alpha 3
CST1 cystatin SN
CTBP2 C-terminal binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EHF ets homologous factor
FABP4 fatty acid binding protein 4, adipocyte
FGFR1 fibroblast growth factor receptor 1
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOXB6 homeobox B6
ICAM1 intercellular adhesion molecule 1
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KLF4 Kruppel-like factor 4 (gut)
LPAR1 lysophosphatidic acid receptor 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MLPH melanophilin
NKG7 natural killer cell granule protein 7
NPC1 Niemann-Pick disease, type C1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAU plasminogen activator, urokinase
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RGS4 regulator of G-protein signaling 4
SCGB2A2 secretoglobin, family 2A, member 2
SMAD3 SMAD family member 3
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
STC1 stanniocalcin 1
STOM stomatin
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TUBA1A tubulin, alpha 1a
VCAN versican
VCL vinculin
VIM vimentin
ZBTB38 zinc finger and BTB domain containing 38
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APLP2 amyloid beta (A4) precursor-like protein 2
BACE2 beta-site APP-cleaving enzyme 2
BST2 bone marrow stromal cell antigen 2
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCND2 cyclin D2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFI complement factor I
CLU clusterin
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF5 eukaryotic translation initiation factor 5
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GPM6B glycoprotein M6B
GSTA1 glutathione S-transferase alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IL13RA2 interleukin 13 receptor, alpha 2
LTF lactotransferrin
METTL7A methyltransferase like 7A
MYLK myosin light chain kinase
NOV nephroblastoma overexpressed
NPC2 Niemann-Pick disease, type C2
PHGDH phosphoglycerate dehydrogenase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD1 SMAD family member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TSPAN13 tetraspanin 13
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)