BRD-K94012289_OSI-027_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K94012289_OSI-027_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADCK3 aarF domain containing kinase 3
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANGPT1 angiopoietin 1
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
C6ORF48 chromosome 6 open reading frame 48
CA2 carbonic anhydrase II
CCDC85B coiled-coil domain containing 85B
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCR4 chemokine (C-X-C motif) receptor 4
ECM1 extracellular matrix protein 1
FAR2 fatty acyl CoA reductase 2
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPM6B glycoprotein M6B
GSDMB gasdermin B
H1FX H1 histone family, member X
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRS2 insulin receptor substrate 2
KIAA0355 KIAA0355
KLF11 Kruppel-like factor 11
KLF2 Kruppel-like factor 2
LETMD1 LETM1 domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP7 matrix metallopeptidase 7
N4BP2L1 NEDD4 binding protein 2-like 1
NT5E 5'-nucleotidase, ecto (CD73)
PDE4B phosphodiesterase 4B, cAMP-specific
PGLS 6-phosphogluconolactonase
PILRB paired immunoglobin-like type 2 receptor beta
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRODH proline dehydrogenase (oxidase) 1
PTPRO protein tyrosine phosphatase, receptor type, O
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS5 regulator of G-protein signaling 5
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI2 tissue factor pathway inhibitor 2
TRAPPC6A trafficking protein particle complex 6A
VAT1 vesicle amine transport 1
WEE1 WEE1 G2 checkpoint kinase
YPEL1 yippee-like 1 (Drosophila)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AFP alpha-fetoprotein
AK4 adenylate kinase 4
ARF4 ADP-ribosylation factor 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALU calumenin
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CD24 CD24 molecule
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CLU clusterin
COL5A1 collagen, type V, alpha 1
COMMD8 COMM domain containing 8
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
ELL2 elongation factor, RNA polymerase II, 2
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FAM98A family with sequence similarity 98, member A
FGFR4 fibroblast growth factor receptor 4
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GCLM glutamate-cysteine ligase, modifier subunit
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC59 leucine rich repeat containing 59
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPTX2 neuronal pentraxin II
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OAT ornithine aminotransferase
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCTP phosphatidylcholine transfer protein
PDIA3 protein disulfide isomerase family A, member 3
PEG10 paternally expressed 10
PGC progastricsin (pepsinogen C)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PRDX1 peroxiredoxin 1
PSPH phosphoserine phosphatase
PTN pleiotrophin
RIT1 Ras-like without CAAX 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEC24D SEC24 family member D
SELT selenoprotein T
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOAT1 sterol O-acyltransferase 1
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TBL1X transducin (beta)-like 1X-linked
TFRC transferrin receptor
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VDAC1 voltage-dependent anion channel 1
YARS tyrosyl-tRNA synthetase