BRD-K94012289_OSI-027_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

257 genes differentially expressed following the BRD-K94012289_OSI-027_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AMDHD2 amidohydrolase domain containing 2
ANKRD36 ankyrin repeat domain 36
ANKRD36B ankyrin repeat domain 36B
ASPN asporin
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
BGN biglycan
BRD3 bromodomain containing 3
C14ORF132 chromosome 14 open reading frame 132
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCDC85B coiled-coil domain containing 85B
CCNG1 cyclin G1
CCNI cyclin I
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP57 centrosomal protein 57kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
COL10A1 collagen, type X, alpha 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSD cathepsin D
CTSK cathepsin K
CUTA cutA divalent cation tolerance homolog (E. coli)
CYBRD1 cytochrome b reductase 1
DALRD3 DALR anticodon binding domain containing 3
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EIF2D eukaryotic translation initiation factor 2D
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF4B eukaryotic translation initiation factor 4B
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPCAM epithelial cell adhesion molecule
ESD esterase D
ETHE1 ethylmalonic encephalopathy 1
EVL Enah/Vasp-like
F2R coagulation factor II (thrombin) receptor
FAR2 fatty acyl CoA reductase 2
FOXN3 forkhead box N3
FXR1 fragile X mental retardation, autosomal homolog 1
GALC galactosylceramidase
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GLG1 golgi glycoprotein 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
GSTK1 glutathione S-transferase kappa 1
GUSB glucuronidase, beta
HAUS4 HAUS augmin-like complex, subunit 4
HDAC6 histone deacetylase 6
HEBP1 heme binding protein 1
HEXB hexosaminidase B (beta polypeptide)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOOK2 hook microtubule-tethering protein 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM5D lysine (K)-specific demethylase 5D
KLF13 Kruppel-like factor 13
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LINC00342 long intergenic non-protein coding RNA 342
LTA4H leukotriene A4 hydrolase
MAN1C1 mannosidase, alpha, class 1C, member 1
MCOLN1 mucolipin 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MID1 midline 1
MMP11 matrix metallopeptidase 11
MMP7 matrix metallopeptidase 7
N4BP2L1 NEDD4 binding protein 2-like 1
NONO non-POU domain containing, octamer-binding
NOTCH1 notch 1
NPC2 Niemann-Pick disease, type C2
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
OSBPL1A oxysterol binding protein-like 1A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP6 poly (ADP-ribose) polymerase family, member 6
PGLS 6-phosphogluconolactonase
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
POSTN periostin, osteoblast specific factor
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
QARS glutaminyl-tRNA synthetase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
SFRP4 secreted frizzled-related protein 4
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPG11 spastic paraplegia 11 (autosomal recessive)
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
SULF1 sulfatase 1
SURF1 surfeit 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
YPEL1 yippee-like 1 (Drosophila)
ZNF277 zinc finger protein 277
ZNF32 zinc finger protein 32

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADAM19 ADAM metallopeptidase domain 19
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ARG2 arginase 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BLNK B-cell linker
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1ORF116 chromosome 1 open reading frame 116
CALU calumenin
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD47 CD47 molecule
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
EGF epidermal growth factor
ELOVL6 ELOVL fatty acid elongase 6
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM98A family with sequence similarity 98, member A
FASTKD3 FAST kinase domains 3
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GLIPR1 GLI pathogenesis-related 1
GOLT1B golgi transport 1B
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KANK1 KN motif and ankyrin repeat domains 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT4 keratin 4, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LGMN legumain
LRRC59 leucine rich repeat containing 59
LSM1 LSM1, U6 small nuclear RNA associated
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED21 mediator complex subunit 21
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL13 mitochondrial ribosomal protein L13
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MYCBP MYC binding protein
NAV3 neuron navigator 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NT5DC2 5'-nucleotidase domain containing 2
ODC1 ornithine decarboxylase 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDIA6 protein disulfide isomerase family A, member 6
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM3 phosphoglucomutase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PYCR1 pyrroline-5-carboxylate reductase 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A4 S100 calcium binding protein A4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRG1 stimulator of chondrogenesis 1
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SELT selenoprotein T
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
STK17A serine/threonine kinase 17a
SUB1 SUB1 homolog (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TNC tenascin C
TNS1 tensin 1
TUBB2A tubulin, beta 2A class IIa
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase