BRD-K94012289_OSI-027_HA1E_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K94012289_OSI-027_HA1E_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AMIGO2 adhesion molecule with Ig-like domain 2
ASPN asporin
BGN biglycan
C2CD2 C2 calcium-dependent domain containing 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CPT1A carnitine palmitoyltransferase 1A (liver)
DLC1 DLC1 Rho GTPase activating protein
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FLRT2 fibronectin leucine rich transmembrane protein 2
GOLGA8H golgin A8 family, member H
GSN gelsolin
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INA internexin neuronal intermediate filament protein, alpha
INHBA inhibin, beta A
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAMC2 laminin, gamma 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
N4BP2L2 NEDD4 binding protein 2-like 2
NNMT nicotinamide N-methyltransferase
NOTCH2NL notch 2 N-terminal like
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDLIM5 PDZ and LIM domain 5
PRKCQ protein kinase C, theta
RTN1 reticulon 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SQRDL sulfide quinone reductase-like (yeast)
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TRAPPC10 trafficking protein particle complex 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN7 tetraspanin 7
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD24 CD24 molecule
CHPT1 choline phosphotransferase 1
CISD1 CDGSH iron sulfur domain 1
DDIT4 DNA-damage-inducible transcript 4
ELL2 elongation factor, RNA polymerase II, 2
FAM162A family with sequence similarity 162, member A
FOLR1 folate receptor 1 (adult)
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HP haptoglobin
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGLV2-23 immunoglobulin lambda variable 2-23
KRT15 keratin 15, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NDRG1 N-myc downstream regulated 1
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
QPRT quinolinate phosphoribosyltransferase
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SDC1 syndecan 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNX11 sorting nexin 11
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
TARS threonyl-tRNA synthetase
TFRC transferrin receptor
TRIM29 tripartite motif containing 29
VLDLR very low density lipoprotein receptor