BRD-K94012289_OSI-027_BT20_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K94012289_OSI-027_BT20_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AQP3 aquaporin 3 (Gill blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C1RL complement component 1, r subcomponent-like
CDK19 cyclin-dependent kinase 19
CDK6 cyclin-dependent kinase 6
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CSF1R colony stimulating factor 1 receptor
CST3 cystatin C
CTSB cathepsin B
CYTH1 cytohesin 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLG5 discs, large homolog 5 (Drosophila)
DYNLRB1 dynein, light chain, roadblock-type 1
EAPP E2F-associated phosphoprotein
ECHDC2 enoyl CoA hydratase domain containing 2
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
FYB FYN binding protein
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
H1FX H1 histone family, member X
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSPA1A heat shock 70kDa protein 1A
IGFBP6 insulin-like growth factor binding protein 6
INSR insulin receptor
IRS2 insulin receptor substrate 2
ISLR immunoglobulin superfamily containing leucine-rich repeat
KIAA0753 KIAA0753
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
N4BP2L1 NEDD4 binding protein 2-like 1
NBR1 neighbor of BRCA1 gene 1
NCOA2 nuclear receptor coactivator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PDGFC platelet derived growth factor C
PNRC1 proline-rich nuclear receptor coactivator 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCQ protein kinase C, theta
PSAP prosaposin
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB31 RAB31, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SPRED2 sprouty-related, EVH1 domain containing 2
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRAPPC6A trafficking protein particle complex 6A
USP34 ubiquitin specific peptidase 34
VCAN versican
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACAT2 acetyl-CoA acetyltransferase 2
ADAT1 adenosine deaminase, tRNA-specific 1
AK4 adenylate kinase 4
AKR1C3 aldo-keto reductase family 1, member C3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBP1 fructose-1,6-bisphosphatase 1
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GREM1 gremlin 1, DAN family BMP antagonist
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HOMER1 homer scaffolding protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
MCM10 minichromosome maintenance complex component 10
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHB prohibitin
PNP purine nucleoside phosphorylase
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS3 protease, serine, 3
QDPR quinoid dihydropteridine reductase
RFC2 replication factor C (activator 1) 2, 40kDa
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SRPRB signal recognition particle receptor, B subunit
SYNM synemin, intermediate filament protein
TMEM47 transmembrane protein 47
TUBB6 tubulin, beta 6 class V
VDAC1 voltage-dependent anion channel 1
VIM vimentin