BRD-K93725829_ERK inhibitor 11e_U937_6.0_h_0.5_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_U937_6.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK6 cyclin-dependent kinase 6
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA2 chloride channel accessory 2
CNOT4 CCR4-NOT transcription complex, subunit 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EGLN3 egl-9 family hypoxia-inducible factor 3
ELL2 elongation factor, RNA polymerase II, 2
EPAS1 endothelial PAS domain protein 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FABP4 fatty acid binding protein 4, adipocyte
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FOXF1 forkhead box F1
FOXG1 forkhead box G1
FZD7 frizzled class receptor 7
GAS6 growth arrest-specific 6
GPC4 glypican 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BG histone cluster 1, H2bg
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IL13RA1 interleukin 13 receptor, alpha 1
IL33 interleukin 33
IPO13 importin 13
ITM2C integral membrane protein 2C
KLF5 Kruppel-like factor 5 (intestinal)
LMO3 LIM domain only 3 (rhombotin-like 2)
LRMP lymphoid-restricted membrane protein
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MPO myeloperoxidase
MUC2 mucin 2, oligomeric mucus/gel-forming
NT5E 5'-nucleotidase, ecto (CD73)
PEG10 paternally expressed 10
PPOX protoporphyrinogen oxidase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAI14 retinoic acid induced 14
REG1B regenerating islet-derived 1 beta
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD5 stearoyl-CoA desaturase 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRG1 stimulator of chondrogenesis 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SH3BGRL SH3 domain binding glutamate-rich protein like
SHB Src homology 2 domain containing adaptor protein B
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK4 serine peptidase inhibitor, Kazal type 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBI transforming growth factor, beta-induced, 68kDa
THSD7A thrombospondin, type I, domain containing 7A
TKTL1 transketolase-like 1
TNS3 tensin 3
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
WNT5B wingless-type MMTV integration site family, member 5B
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BIN1 bridging integrator 1
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CELF2 CUGBP, Elav-like family member 2
CHPT1 choline phosphotransferase 1
CKAP4 cytoskeleton-associated protein 4
COBL cordon-bleu WH2 repeat protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFS embryonal Fyn-associated substrate
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EVL Enah/Vasp-like
EXOSC4 exosome component 4
FBXL5 F-box and leucine-rich repeat protein 5
FBXO21 F-box protein 21
GBP1 guanylate binding protein 1, interferon-inducible
GTPBP8 GTP-binding protein 8 (putative)
HOMER1 homer scaffolding protein 1
IGF1R insulin-like growth factor 1 receptor
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
KRT7 keratin 7, type II
LAMA2 laminin, alpha 2
LEPROTL1 leptin receptor overlapping transcript-like 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAAA N-acylethanolamine acid amidase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NUP98 nucleoporin 98kDa
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PHACTR2 phosphatase and actin regulator 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTX3 pentraxin 3, long
RAB2A RAB2A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SORD sorbitol dehydrogenase
THBS2 thrombospondin 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRBC1 T cell receptor beta constant 1
UBXN8 UBX domain protein 8
XPO7 exportin 7