BRD-K93725829_ERK inhibitor 11e_HCT116_6.0_h_0.5_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_HCT116_6.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
APOA1 apolipoprotein A-I
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C1S complement component 1, s subcomponent
CALD1 caldesmon 1
CCDC85B coiled-coil domain containing 85B
CCND2 cyclin D2
CD99 CD99 molecule
CDK14 cyclin-dependent kinase 14
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHN1 chimerin 1
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CRELD2 cysteine-rich with EGF-like domains 2
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DSP desmoplakin
EFNB3 ephrin-B3
EPAS1 endothelial PAS domain protein 1
FADS3 fatty acid desaturase 3
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HACD1 3-hydroxyacyl-CoA dehydratase 1
HTRA1 HtrA serine peptidase 1
KRT17 keratin 17, type I
LDOC1 leucine zipper, down-regulated in cancer 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE8B phosphodiesterase 8B
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PRKCI protein kinase C, iota
PROSC proline synthetase co-transcribed homolog (bacterial)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RBP4 retinol binding protein 4, plasma
RDX radixin
RHOBTB3 Rho-related BTB domain containing 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SPINK1 serine peptidase inhibitor, Kazal type 1
TARP TCR gamma alternate reading frame protein
THBS1 thrombospondin 1
TRIM29 tripartite motif containing 29
TSPAN13 tetraspanin 13
UBE2J1 ubiquitin-conjugating enzyme E2, J1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRD10 ankyrin repeat domain 10
ANO1 anoctamin 1, calcium activated chloride channel
CALML5 calmodulin-like 5
CAPN2 calpain 2, (m/II) large subunit
CCND1 cyclin D1
CD302 CD302 molecule
CD34 CD34 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP170 centrosomal protein 170kDa
CHSY1 chondroitin sulfate synthase 1
COL6A2 collagen, type VI, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DNMBP dynamin binding protein
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGL2 fibrinogen-like 2
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
KLF11 Kruppel-like factor 11
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LSR lipolysis stimulated lipoprotein receptor
LTBP3 latent transforming growth factor beta binding protein 3
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
OXA1L oxidase (cytochrome c) assembly 1-like
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLCB4 phospholipase C, beta 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROCR protein C receptor, endothelial
PROM1 prominin 1
PRSS3 protease, serine, 3
PSD3 pleckstrin and Sec7 domain containing 3
RBPMS RNA binding protein with multiple splicing
RNMT RNA (guanine-7-) methyltransferase
SACS sacsin molecular chaperone
SH2B3 SH2B adaptor protein 3
SHB Src homology 2 domain containing adaptor protein B
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM5 transmembrane protein 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
ZNF330 zinc finger protein 330