BRD-K93623501_NCGC00186101-01_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

210 genes differentially expressed following the BRD-K93623501_NCGC00186101-01_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZU1 azurocidin 1
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CALR calreticulin
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC11A C-type lectin domain family 11, member A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
DEFA5 defensin, alpha 5, Paneth cell-specific
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ELANE elastase, neutrophil expressed
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP6 fatty acid binding protein 6, ileal
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FRY furry homolog (Drosophila)
FST follistatin
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
HEPH hephaestin
HHEX hematopoietically expressed homeobox
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
HOXB5 homeobox B5
HOXB6 homeobox B6
IL13RA1 interleukin 13 receptor, alpha 1
IPO13 importin 13
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM6A lysine (K)-specific demethylase 6A
KRT20 keratin 20, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100272216 uncharacterized LOC100272216
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
MAST4 microtubule associated serine/threonine kinase family member 4
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MPO myeloperoxidase
MYOF myoferlin
NELL2 NEL-like 2 (chicken)
NFE2 nuclear factor, erythroid 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PBX3 pre-B-cell leukemia homeobox 3
PLAU plasminogen activator, urokinase
PLN phospholamban
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PYCARD PYD and CARD domain containing
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
UBE2A ubiquitin-conjugating enzyme E2A
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF1 activating transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CETN3 centrin, EF-hand protein, 3
CHEK2 checkpoint kinase 2
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
CIT citron rho-interacting serine/threonine kinase
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EBNA1BP2 EBNA1 binding protein 2
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPSM2 G-protein signaling modulator 2
GPX3 glutathione peroxidase 3
GTPBP8 GTP-binding protein 8 (putative)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLF hepatic leukemia factor
HLTF helicase-like transcription factor
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KRT10 keratin 10, type I
KRT14 keratin 14, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MARCKSL1 MARCKS-like 1
MCOLN1 mucolipin 1
MLF1 myeloid leukemia factor 1
MPZL1 myelin protein zero-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NBN nibrin
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NMU neuromedin U
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
OXR1 oxidation resistance 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PUF60 poly-U binding splicing factor 60KDa
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPS11 ribosomal protein S11
S100A13 S100 calcium binding protein A13
SFN stratifin
SGCE sarcoglycan, epsilon
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A46 solute carrier family 25, member 46
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SRSF11 serine/arginine-rich splicing factor 11
TBC1D16 TBC1 domain family, member 16
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WRB tryptophan rich basic protein
ZNF185 zinc finger protein 185 (LIM domain)