BRD-K93480852_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K93480852_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATM ATM serine/threonine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BMP4 bone morphogenetic protein 4
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
CPA3 carboxypeptidase A3 (mast cell)
CST6 cystatin E/M
CSTA cystatin A (stefin A)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPCAM epithelial cell adhesion molecule
ESRP1 epithelial splicing regulatory protein 1
F11R F11 receptor
FAM129A family with sequence similarity 129, member A
FAM60A family with sequence similarity 60, member A
GRB10 growth factor receptor-bound protein 10
GRB7 growth factor receptor-bound protein 7
HIST1H2BG histone cluster 1, H2bg
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
POSTN periostin, osteoblast specific factor
PPL periplakin
PTPRK protein tyrosine phosphatase, receptor type, K
QPCT glutaminyl-peptide cyclotransferase
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SPINK1 serine peptidase inhibitor, Kazal type 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ANXA6 annexin A6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AXL AXL receptor tyrosine kinase
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLU clusterin
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EBNA1BP2 EBNA1 binding protein 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FLNA filamin A, alpha
GSTM3 glutathione S-transferase mu 3 (brain)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL13RA2 interleukin 13 receptor, alpha 2
KPNB1 karyopherin (importin) beta 1
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LEPR leptin receptor
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
MYCBP MYC binding protein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP62 nucleoporin 62kDa
ODC1 ornithine decarboxylase 1
PALLD palladin, cytoskeletal associated protein
PDLIM2 PDZ and LIM domain 2 (mystique)
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAE1 ribonucleic acid export 1
RBM25 RNA binding motif protein 25
RHOB ras homolog family member B
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SCRG1 stimulator of chondrogenesis 1
SORBS3 sorbin and SH3 domain containing 3
SRGN serglycin
TFAM transcription factor A, mitochondrial
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase