BRD-K93480852_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K93480852_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
ANO10 anoctamin 10
ANXA3 annexin A3
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN3 claudin 3
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
ENO2 enolase 2 (gamma, neuronal)
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
INSIG1 insulin induced gene 1
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
LPIN1 lipin 1
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
NRN1 neuritin 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLAT plasminogen activator, tissue
PLCB4 phospholipase C, beta 4
PNMA2 paraneoplastic Ma antigen 2
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SDCBP syndecan binding protein (syntenin)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
STMN2 stathmin 2
TAC1 tachykinin, precursor 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAT1 vesicle amine transport 1
VCAN versican
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
COL4A5 collagen, type IV, alpha 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EFHD1 EF-hand domain family, member D1
FAIM Fas apoptotic inhibitory molecule
FEN1 flap structure-specific endonuclease 1
IGKV1-5 immunoglobulin kappa variable 1-5
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
RRM1 ribonucleotide reductase M1
SDC2 syndecan 2
SELL selectin L
SHCBP1 SHC SH2-domain binding protein 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TOR1A torsin family 1, member A (torsin A)
TUBB2A tubulin, beta 2A class IIa
ZWINT ZW10 interacting kinetochore protein