BRD-K93443135_6-(3,5-dimethylisoxazol-4-yl)quinazolin-4(3H)-one 0033-034_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K93443135_6-(3,5-dimethylisoxazol-4-yl)quinazolin-4(3H)-one 0033-034_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP13 A kinase (PRKA) anchor protein 13
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANO10 anoctamin 10
AUTS2 autism susceptibility candidate 2
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CH25H cholesterol 25-hydroxylase
CLIC5 chloride intracellular channel 5
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A3 collagen, type VI, alpha 3
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLRE1C DNA cross-link repair 1C
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNMBP dynamin binding protein
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP1A FK506 binding protein 1A, 12kDa
FOLR1 folate receptor 1 (adult)
G6PD glucose-6-phosphate dehydrogenase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GMDS GDP-mannose 4,6-dehydratase
GOLGA8A golgin A8 family, member A
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BG histone cluster 1, H2bg
HNRNPL heterogeneous nuclear ribonucleoprotein L
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IL13RA1 interleukin 13 receptor, alpha 1
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IRS1 insulin receptor substrate 1
KIAA0355 KIAA0355
KLHL41 kelch-like family member 41
KRT15 keratin 15, type I
LAMA3 laminin, alpha 3
LMCD1 LIM and cysteine-rich domains 1
LPAR1 lysophosphatidic acid receptor 1
LRRC16A leucine rich repeat containing 16A
LTF lactotransferrin
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MB myoglobin
MICB MHC class I polypeptide-related sequence B
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NEB nebulin
NUP210 nucleoporin 210kDa
PALMD palmdelphin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PRR15L proline rich 15-like
PRSS2 protease, serine, 2 (trypsin 2)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG3A regenerating islet-derived 3 alpha
RFTN1 raftlin, lipid raft linker 1
RORA RAR-related orphan receptor A
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TFF3 trefoil factor 3 (intestinal)
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TMOD1 tropomodulin 1
TNNC1 troponin C type 1 (slow)
TPPP3 tubulin polymerization-promoting protein family member 3
TRIM38 tripartite motif containing 38
TRPS1 trichorhinophalangeal syndrome I
TSPYL5 TSPY-like 5
TTN titin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPK1B uroplakin 1B
ZBTB16 zinc finger and BTB domain containing 16
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AEBP1 AE binding protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
BAD BCL2-associated agonist of cell death
BCHE butyrylcholinesterase
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CCNB1 cyclin B1
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
ERGIC3 ERGIC and golgi 3
FAM3C family with sequence similarity 3, member C
FMR1 fragile X mental retardation 1
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
GPX1 glutathione peroxidase 1
H3F3B H3 histone, family 3B (H3.3B)
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
KLF4 Kruppel-like factor 4 (gut)
LEF1 lymphoid enhancer-binding factor 1
LOXL2 lysyl oxidase-like 2
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MOK MOK protein kinase
MRPL22 mitochondrial ribosomal protein L22
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NRIP1 nuclear receptor interacting protein 1
NRIP3 nuclear receptor interacting protein 3
PDHX pyruvate dehydrogenase complex, component X
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLAT plasminogen activator, tissue
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRNP prion protein
PSIP1 PC4 and SFRS1 interacting protein 1
PWP1 PWP1 homolog (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RHOC ras homolog family member C
RND3 Rho family GTPase 3
RNH1 ribonuclease/angiogenin inhibitor 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SARS seryl-tRNA synthetase
SCAND1 SCAN domain containing 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
SRSF5 serine/arginine-rich splicing factor 5
SSRP1 structure specific recognition protein 1
STIP1 stress-induced phosphoprotein 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TIMP3 TIMP metallopeptidase inhibitor 3
TLK2 tousled-like kinase 2
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAPPC3 trafficking protein particle complex 3
TRIM44 tripartite motif containing 44
UBE2S ubiquitin-conjugating enzyme E2S
UFM1 ubiquitin-fold modifier 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
WARS tryptophanyl-tRNA synthetase
ZFP36L1 ZFP36 ring finger protein-like 1