BRD-K93443135_6-(3,5-dimethylisoxazol-4-yl)quinazolin-4(3H)-one 0033-034_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K93443135_6-(3,5-dimethylisoxazol-4-yl)quinazolin-4(3H)-one 0033-034_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACTA1 actin, alpha 1, skeletal muscle
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APMAP adipocyte plasma membrane associated protein
APP amyloid beta (A4) precursor protein
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
BMP4 bone morphogenetic protein 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKAP4 cytoskeleton-associated protein 4
CLGN calmegin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FADS1 fatty acid desaturase 1
FST follistatin
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KRT15 keratin 15, type I
LAMP2 lysosomal-associated membrane protein 2
LPCAT1 lysophosphatidylcholine acyltransferase 1
LY75 lymphocyte antigen 75
MYO6 myosin VI
NEB nebulin
PRR7 proline rich 7 (synaptic)
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
SAMD4A sterile alpha motif domain containing 4A
SCG5 secretogranin V
SH3BGRL SH3 domain binding glutamate-rich protein like
SNX7 sorting nexin 7
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMSB15A thymosin beta 15a
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TTN titin
TUBA1A tubulin, alpha 1a
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BACE2 beta-site APP-cleaving enzyme 2
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLTB clathrin, light chain B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
DMD dystrophin
DYNLT3 dynein, light chain, Tctex-type 3
E2F2 E2F transcription factor 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HOXB6 homeobox B6
JADE2 jade family PHD finger 2
LGALS2 lectin, galactoside-binding, soluble, 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
RASA4 RAS p21 protein activator 4
RBPMS RNA binding protein with multiple splicing
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TIMP3 TIMP metallopeptidase inhibitor 3
TLR4 toll-like receptor 4
TYMP thymidine phosphorylase