BRD-K93215584_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K93215584_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
CAPG capping protein (actin filament), gelsolin-like
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CLDN3 claudin 3
CTSL cathepsin L
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUOX2 dual oxidase 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO3 forkhead box O3
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GRN granulin
HBB hemoglobin, beta
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
NEU1 sialidase 1 (lysosomal sialidase)
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUCB2 nucleobindin 2
OLFM4 olfactomedin 4
PAWR PRKC, apoptosis, WT1, regulator
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PON3 paraoxonase 3
PSAP prosaposin
RAP1GAP RAP1 GTPase activating protein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC16A6 solute carrier family 16, member 6
SLC22A18 solute carrier family 22, member 18
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNNT1 troponin T type 1 (skeletal, slow)
TSKU tsukushi, small leucine rich proteoglycan
TWF2 twinfilin actin binding protein 2
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDK1 cyclin-dependent kinase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS1B CDC28 protein kinase regulatory subunit 1B
COL3A1 collagen, type III, alpha 1
COMMD8 COMM domain containing 8
CSE1L CSE1 chromosome segregation 1-like (yeast)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GHR growth hormone receptor
HACD2 3-hydroxyacyl-CoA dehydratase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC6 homeobox C6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
PBK PDZ binding kinase
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PTDSS1 phosphatidylserine synthase 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1A torsin family 1, member A (torsin A)
UBE2C ubiquitin-conjugating enzyme E2C
WWTR1 WW domain containing transcription regulator 1