BRD-K93123848_RAF 265_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K93123848_RAF 265_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
BEX1 brain expressed, X-linked 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CD24 CD24 molecule
CRISP3 cysteine-rich secretory protein 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EHF ets homologous factor
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
GAS6 growth arrest-specific 6
GRN granulin
GSDMB gasdermin B
HLA-DMA major histocompatibility complex, class II, DM alpha
HSPB8 heat shock 22kDa protein 8
IGKV4-1 immunoglobulin kappa variable 4-1
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
LITAF lipopolysaccharide-induced TNF factor
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
OLFM4 olfactomedin 4
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
QPRT quinolinate phosphoribosyltransferase
SELENBP1 selenium binding protein 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC44A4 solute carrier family 44, member 4
SPINK1 serine peptidase inhibitor, Kazal type 1
TMC5 transmembrane channel-like 5
TXNIP thioredoxin interacting protein
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
AREG amphiregulin
CIAPIN1 cytokine induced apoptosis inhibitor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENOPH1 enolase-phosphatase 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FST follistatin
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
LEF1 lymphoid enhancer-binding factor 1
LOXL2 lysyl oxidase-like 2
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPAT phosphoribosyl pyrophosphate amidotransferase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PUS7 pseudouridylate synthase 7 (putative)
RBMS1 RNA binding motif, single stranded interacting protein 1
RBP1 retinol binding protein 1, cellular
RDX radixin
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TREM1 triggering receptor expressed on myeloid cells 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VCAN versican
XIST X inactive specific transcript (non-protein coding)