BRD-K93123848_RAF 265_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K93123848_RAF 265_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACB acetyl-CoA carboxylase beta
ACSF2 acyl-CoA synthetase family member 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AGR2 anterior gradient 2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMT aminomethyltransferase
BASP1 brain abundant, membrane attached signal protein 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BST2 bone marrow stromal cell antigen 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CP ceruloplasmin (ferroxidase)
CTSS cathepsin S
CYBB cytochrome b-245, beta polypeptide
DAPK1 death-associated protein kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GOLPH3L golgi phosphoprotein 3-like
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSDMB gasdermin B
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
ITM2B integral membrane protein 2B
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
LITAF lipopolysaccharide-induced TNF factor
LY75 lymphocyte antigen 75
MAGED2 melanoma antigen family D2
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
NLGN4X neuroligin 4, X-linked
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PBLD phenazine biosynthesis-like protein domain containing
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBKS ribokinase
REG1A regenerating islet-derived 1 alpha
SELENBP1 selenium binding protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
ADRM1 adhesion regulating molecule 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
AUTS2 autism susceptibility candidate 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CALML5 calmodulin-like 5
CAV1 caveolin 1, caveolae protein, 22kDa
CEMIP cell migration inducing protein, hyaluronan binding
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL5A2 collagen, type V, alpha 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNM1L dynamin 1-like
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP1 epithelial membrane protein 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
INPP1 inositol polyphosphate-1-phosphatase
ITGB1BP1 integrin beta 1 binding protein 1
KLF10 Kruppel-like factor 10
LOXL1 lysyl oxidase-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPTX2 neuronal pentraxin II
ODC1 ornithine decarboxylase 1
PAX5 paired box 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRMT1 protein arginine methyltransferase 1
PRMT5 protein arginine methyltransferase 5
PUF60 poly-U binding splicing factor 60KDa
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC35F2 solute carrier family 35, member F2
SRM spermidine synthase
STIP1 stress-induced phosphoprotein 1
TEX10 testis expressed 10
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TUBB2A tubulin, beta 2A class IIa
UBE2S ubiquitin-conjugating enzyme E2S
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1