BRD-K93123848_RAF 265_HT29_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K93123848_RAF 265_HT29_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
CCND2 cyclin D2
CLCA1 chloride channel accessory 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
COMT catechol-O-methyltransferase
DAP death-associated protein
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPHA3 EPH receptor A3
FSD1 fibronectin type III and SPRY domain containing 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
LAMP1 lysosomal-associated membrane protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZK1IP1 PDZK1 interacting protein 1
PFKL phosphofructokinase, liver
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTX3 pentraxin 3, long
PXMP2 peroxisomal membrane protein 2, 22kDa
QPCT glutaminyl-peptide cyclotransferase
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
REG3A regenerating islet-derived 3 alpha
RNF130 ring finger protein 130
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TRAK2 trafficking protein, kinesin binding 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AIM2 absent in melanoma 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX15B arachidonate 15-lipoxygenase, type B
ANXA1 annexin A1
BMP2 bone morphogenetic protein 2
BPHL biphenyl hydrolase-like (serine hydrolase)
CALB1 calbindin 1, 28kDa
CORO1A coronin, actin binding protein, 1A
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP2 cysteine and glycine-rich protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
EGR3 early growth response 3
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
GPRC5A G protein-coupled receptor, class C, group 5, member A
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INPP1 inositol polyphosphate-1-phosphatase
KCTD12 potassium channel tetramerization domain containing 12
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LRRN3 leucine rich repeat neuronal 3
LTF lactotransferrin
LYRM4 LYR motif containing 4
NELL2 NEL-like 2 (chicken)
NQO1 NAD(P)H dehydrogenase, quinone 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PPAT phosphoribosyl pyrophosphate amidotransferase
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRF1 perforin 1 (pore forming protein)
PYGB phosphorylase, glycogen; brain
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STK17A serine/threonine kinase 17a
STOM stomatin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRBC1 T cell receptor beta constant 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFPM2 zinc finger protein, FOG family member 2