BRD-K93123848_RAF 265_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K93123848_RAF 265_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMACR alpha-methylacyl-CoA racemase
APOE apolipoprotein E
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCHE butyrylcholinesterase
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CBS cystathionine-beta-synthase
CCDC92 coiled-coil domain containing 92
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CES2 carboxylesterase 2
CTBP1 C-terminal binding protein 1
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM63A family with sequence similarity 63, member A
FTH1 ferritin, heavy polypeptide 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUD1 glutamate dehydrogenase 1
GPER1 G protein-coupled estrogen receptor 1
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
LPL lipoprotein lipase
MAGED2 melanoma antigen family D2
MAP1B microtubule-associated protein 1B
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NR1D2 nuclear receptor subfamily 1, group D, member 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RBKS ribokinase
RGS1 regulator of G-protein signaling 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SESN1 sestrin 1
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLA Src-like-adaptor
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TPD52L1 tumor protein D52-like 1
TXNIP thioredoxin interacting protein
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
BMP4 bone morphogenetic protein 4
CALD1 caldesmon 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CLU clusterin
COL6A3 collagen, type VI, alpha 3
CSRP2 cysteine and glycine-rich protein 2
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGR1 early growth response 1
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM3C family with sequence similarity 3, member C
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HOXB6 homeobox B6
HOXB7 homeobox B7
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGB1BP1 integrin beta 1 binding protein 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
KIF5C kinesin family member 5C
LDLR low density lipoprotein receptor
MT1E metallothionein 1E
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUAK1 NUAK family, SNF1-like kinase, 1
PDHX pyruvate dehydrogenase complex, component X
PHLDA2 pleckstrin homology-like domain, family A, member 2
RGS4 regulator of G-protein signaling 4
SELE selectin E
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMS spermine synthase
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TPM2 tropomyosin 2 (beta)
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V