BRD-K93123848_RAF 265_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K93123848_RAF 265_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CES1 carboxylesterase 1
CHRDL1 chordin-like 1
CSTA cystatin A (stefin A)
DACH1 dachshund family transcription factor 1
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDIT4 DNA-damage-inducible transcript 4
EFHD1 EF-hand domain family, member D1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP1 insulin-like growth factor binding protein 1
INSM1 insulinoma-associated 1
KIAA1598
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
LOX lysyl oxidase
LPL lipoprotein lipase
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MARS methionyl-tRNA synthetase
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTUS1 microtubule associated tumor suppressor 1
MYO10 myosin X
NOVA1 neuro-oncological ventral antigen 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHGDH phosphoglycerate dehydrogenase
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PON3 paraoxonase 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP2 syntaxin binding protein 2
TCTA T-cell leukemia translocation altered
THBS1 thrombospondin 1
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CTSV cathepsin V
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
EXOSC4 exosome component 4
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA2 heat shock 70kDa protein 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100505650 uncharacterized LOC100505650
MSMO1 methylsterol monooxygenase 1
MYH11 myosin, heavy chain 11, smooth muscle
PAM peptidylglycine alpha-amidating monooxygenase
PKP1 plakophilin 1
PRDX2 peroxiredoxin 2
RBPMS RNA binding protein with multiple splicing
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SOX4 SRY (sex determining region Y)-box 4
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SQLE squalene epoxidase
TAGLN transgelin
TNC tenascin C
TPD52L2 tumor protein D52-like 2
VSNL1 visinin-like 1