BRD-K93123848_RAF 265_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

52 genes differentially expressed following the BRD-K93123848_RAF 265_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1C3 aldo-keto reductase family 1, member C3
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CST3 cystatin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
GPX2 glutathione peroxidase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
POSTN periostin, osteoblast specific factor
S100A9 S100 calcium binding protein A9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SYT1 synaptotagmin I
TPD52L1 tumor protein D52-like 1
VCAN versican
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
CLU clusterin
DHCR24 24-dehydrocholesterol reductase
ENO3 enolase 3 (beta, muscle)
FADS1 fatty acid desaturase 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPM6B glycoprotein M6B
GTPBP8 GTP-binding protein 8 (putative)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP7 insulin-like growth factor binding protein 7
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTB lymphotoxin beta (TNF superfamily, member 3)
MCAM melanoma cell adhesion molecule
MGP matrix Gla protein
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSPH phosphoserine phosphatase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SRGN serglycin
STC1 stanniocalcin 1
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN1 tetraspanin 1