BRD-K93123848_RAF 265_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K93123848_RAF 265_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CA1 carbonic anhydrase I
CALML3 calmodulin-like 3
CFD complement factor D (adipsin)
CLIC4 chloride intracellular channel 4
CPA3 carboxypeptidase A3 (mast cell)
CRISP3 cysteine-rich secretory protein 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP5 dual specificity phosphatase 5
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GANAB glucosidase, alpha; neutral AB
GARS glycyl-tRNA synthetase
HIST1H2AC histone cluster 1, H2ac
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
KIAA0100 KIAA0100
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LDLR low density lipoprotein receptor
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PDGFD platelet derived growth factor D
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSAT1 phosphoserine aminotransferase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ALOX15B arachidonate 15-lipoxygenase, type B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
BATF3 basic leucine zipper transcription factor, ATF-like 3
BIRC5 baculoviral IAP repeat containing 5
C3 complement component 3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CRABP2 cellular retinoic acid binding protein 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
EFHD1 EF-hand domain family, member D1
ELF5 E74-like factor 5 (ets domain transcription factor)
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FAM69A family with sequence similarity 69, member A
FANCI Fanconi anemia, complementation group I
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
IGFBP3 insulin-like growth factor binding protein 3
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRT17 keratin 17, type I
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PGAM1 phosphoglycerate mutase 1 (brain)
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PRKCH protein kinase C, eta
PSRC1 proline/serine-rich coiled-coil 1
QPRT quinolinate phosphoribosyltransferase
RAD51C RAD51 paralog C
RRM2 ribonucleotide reductase M2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
TMEM255A transmembrane protein 255A
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)