BRD-K93123848_RAF 265_HCC515_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K93123848_RAF 265_HCC515_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
C6ORF48 chromosome 6 open reading frame 48
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRIP1 cysteine-rich protein 1 (intestinal)
CTSD cathepsin D
CYB561 cytochrome b561
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DRAM1 DNA-damage regulated autophagy modulator 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
KLF2 Kruppel-like factor 2
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LY96 lymphocyte antigen 96
MAPT microtubule-associated protein tau
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MLPH melanophilin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
OXA1L oxidase (cytochrome c) assembly 1-like
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PYCR1 pyrroline-5-carboxylate reductase 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RRAGD Ras-related GTP binding D
S100A14 S100 calcium binding protein A14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM14B transmembrane protein 14B
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIM8 tripartite motif containing 8
UFM1 ubiquitin-fold modifier 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA4 annexin A4
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
C3 complement component 3
C7 complement component 7
CCDC86 coiled-coil domain containing 86
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CDK1 cyclin-dependent kinase 1
CSRP2 cysteine and glycine-rich protein 2
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
GINS1 GINS complex subunit 1 (Psf1 homolog)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXB7 homeobox B7
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IRF8 interferon regulatory factor 8
KIF14 kinesin family member 14
MGLL monoglyceride lipase
NCAPG non-SMC condensin I complex, subunit G
NELL2 NEL-like 2 (chicken)
NREP neuronal regeneration related protein
OPN3 opsin 3
PCDH7 protocadherin 7
RAD51AP1 RAD51 associated protein 1
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNX10 sorting nexin 10
SPDL1 spindle apparatus coiled-coil protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
VLDLR very low density lipoprotein receptor
XIST X inactive specific transcript (non-protein coding)