BRD-K93123848_RAF 265_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K93123848_RAF 265_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
ATP10B ATPase, class V, type 10B
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COBL cordon-bleu WH2 repeat protein
COL9A2 collagen, type IX, alpha 2
CSRP1 cysteine and glycine-rich protein 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FMOD fibromodulin
GATA3 GATA binding protein 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
KIAA1598
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY96 lymphocyte antigen 96
METTL7A methyltransferase like 7A
MSRB2 methionine sulfoxide reductase B2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NCAM1 neural cell adhesion molecule 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRAF2 PRA1 domain family, member 2
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SARS seryl-tRNA synthetase
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC22A18 solute carrier family 22, member 18
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SSPN sarcospan
SYT11 synaptotagmin XI
VAT1 vesicle amine transport 1
WFDC2 WAP four-disulfide core domain 2
XPOT exportin, tRNA

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
BAG3 BCL2-associated athanogene 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CCND1 cyclin D1
CD24 CD24 molecule
CLU clusterin
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYTL1 cytokine-like 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFHD1 EF-hand domain family, member D1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
EPHA3 EPH receptor A3
EZR ezrin
FBN2 fibrillin 2
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IL13RA2 interleukin 13 receptor, alpha 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAMB1 laminin, beta 1
MYO1B myosin IB
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNP purine nucleoside phosphorylase
RBM47 RNA binding motif protein 47
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SDC1 syndecan 1
SDC2 syndecan 2
SHB Src homology 2 domain containing adaptor protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPRR3 small proline-rich protein 3
STX1A syntaxin 1A (brain)
TACC1 transforming, acidic coiled-coil containing protein 1
TMEM2 transmembrane protein 2
TMEM70 transmembrane protein 70
TMEM97 transmembrane protein 97
TSPAN5 tetraspanin 5
VSNL1 visinin-like 1