BRD-K93123848_RAF 265_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K93123848_RAF 265_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
BMP4 bone morphogenetic protein 4
CBS cystathionine-beta-synthase
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
CHRDL1 chordin-like 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
GARS glycyl-tRNA synthetase
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
JCHAIN joining chain of multimeric IgA and IgM
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYH11 myosin, heavy chain 11, smooth muscle
OLFM4 olfactomedin 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCR1 pyrroline-5-carboxylate reductase 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
APP amyloid beta (A4) precursor protein
ASPH aspartate beta-hydroxylase
CD9 CD9 molecule
CDC42 cell division cycle 42
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
DSP desmoplakin
EMP1 epithelial membrane protein 1
FABP7 fatty acid binding protein 7, brain
FN1 fibronectin 1
GJA1 gap junction protein, alpha 1, 43kDa
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HK2 hexokinase 2
HOPX HOP homeobox
HOXB7 homeobox B7
IL1R2 interleukin 1 receptor, type II
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT17 keratin 17, type I
LYPD3 LY6/PLAUR domain containing 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MSH6 mutS homolog 6
NRIP3 nuclear receptor interacting protein 3
PEG3 paternally expressed 3
PI3 peptidase inhibitor 3, skin-derived
QPCT glutaminyl-peptide cyclotransferase
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SOSTDC1 sclerostin domain containing 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TMEM97 transmembrane protein 97
TOB1 transducer of ERBB2, 1
XIST X inactive specific transcript (non-protein coding)