BRD-K93080877_Ala-Ala-Phe-CMK_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K93080877_Ala-Ala-Phe-CMK_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
CA2 carbonic anhydrase II
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRISP3 cysteine-rich secretory protein 3
CTNND1 catenin (cadherin-associated protein), delta 1
CTSK cathepsin K
DENND1B DENN/MADD domain containing 1B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT15 keratin 15, type I
LXN latexin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEST mesoderm specific transcript
MN1 meningioma (disrupted in balanced translocation) 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NQO1 NAD(P)H dehydrogenase, quinone 1
NXN nucleoredoxin
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIR pirin (iron-binding nuclear protein)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAP prosaposin
RANBP9 RAN binding protein 9
RGCC regulator of cell cycle
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCE sarcoglycan, epsilon
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRE5 adhesion G protein-coupled receptor E5
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CHGB chromogranin B
CHMP6 charged multivesicular body protein 6
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
EIF5B eukaryotic translation initiation factor 5B
EREG epiregulin
HOXC6 homeobox C6
IGFBP3 insulin-like growth factor binding protein 3
L1CAM L1 cell adhesion molecule
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PPARG peroxisome proliferator-activated receptor gamma
QDPR quinoid dihydropteridine reductase
S100A2 S100 calcium binding protein A2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TSEN2 TSEN2 tRNA splicing endonuclease subunit