BRD-K93060291_TL_HRAS24 BRD-K93060291_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K93060291_TL_HRAS24 BRD-K93060291_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BEX1 brain expressed, X-linked 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD200 CD200 molecule
CD38 CD38 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DARS aspartyl-tRNA synthetase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
ENAH enabled homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
ETV5 ets variant 5
FABP7 fatty acid binding protein 7, brain
FGL2 fibrinogen-like 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FOXJ3 forkhead box J3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX2 glutathione peroxidase 2
GTPBP8 GTP-binding protein 8 (putative)
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA2 heat shock 70kDa protein 2
IDO1 indoleamine 2,3-dioxygenase 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0753 KIAA0753
KLHL21 kelch-like family member 21
LEFTY1 left-right determination factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100272216 uncharacterized LOC100272216
LOC100505650 uncharacterized LOC100505650
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK13 mitogen-activated protein kinase 13
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPEPPS aminopeptidase puromycin sensitive
NQO1 NAD(P)H dehydrogenase, quinone 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PENK proenkephalin
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIR pirin (iron-binding nuclear protein)
PLN phospholamban
PNMA2 paraneoplastic Ma antigen 2
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PRR15L proline rich 15-like
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RNF44 ring finger protein 44
RPL39L ribosomal protein L39-like
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNX10 sorting nexin 10
SPRY2 sprouty homolog 2 (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX3 syntaxin 3
STXBP1 syntaxin binding protein 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TMCC1 transmembrane and coiled-coil domain family 1
TMEM41B transmembrane protein 41B
TRAF5 TNF receptor-associated factor 5
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ANXA3 annexin A3
ARF1 ADP-ribosylation factor 1
ARHGAP29 Rho GTPase activating protein 29
BID BH3 interacting domain death agonist
CCNA1 cyclin A1
CCNE2 cyclin E2
CDC42 cell division cycle 42
CLC Charcot-Leyden crystal galectin
CLGN calmegin
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CSRP2 cysteine and glycine-rich protein 2
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
ETV1 ets variant 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GDI2 GDP dissociation inhibitor 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTRA1 HtrA serine peptidase 1
INHBB inhibin, beta B
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
MT1F metallothionein 1F
MT1X metallothionein 1X
NID2 nidogen 2 (osteonidogen)
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PSD3 pleckstrin and Sec7 domain containing 3
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS10 regulator of G-protein signaling 10
RIN2 Ras and Rab interactor 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC4 syndecan 4
SERF2 small EDRK-rich factor 2
SGCE sarcoglycan, epsilon
ST7 suppression of tumorigenicity 7
TDO2 tryptophan 2,3-dioxygenase
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TNS3 tensin 3
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TST thiosulfate sulfurtransferase (rhodanese)
USP22 ubiquitin specific peptidase 22