BRD-K93060291_TL_HRAS24 BRD-K93060291_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K93060291_TL_HRAS24 BRD-K93060291_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY2 adenylate cyclase 2 (brain)
ADM adrenomedullin
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CD52 CD52 molecule
CD9 CD9 molecule
CLDN3 claudin 3
CTGF connective tissue growth factor
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF4A1 eukaryotic translation initiation factor 4A1
EZR ezrin
FBP1 fructose-1,6-bisphosphatase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KRT23 keratin 23, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP2 microfibrillar-associated protein 2
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTHLH parathyroid hormone-like hormone
RGS4 regulator of G-protein signaling 4
RIN2 Ras and Rab interactor 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SIK1 salt-inducible kinase 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TWIST1 twist family bHLH transcription factor 1
TYMP thymidine phosphorylase
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
ASRGL1 asparaginase like 1
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CRIP1 cysteine-rich protein 1 (intestinal)
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM117A family with sequence similarity 117, member A
FAM171A1 family with sequence similarity 171, member A1
FUCA1 fucosidase, alpha-L- 1, tissue
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
IL6ST interleukin 6 signal transducer
LDHB lactate dehydrogenase B
LEPR leptin receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
MGP matrix Gla protein
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCP4 Purkinje cell protein 4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SORD sorbitol dehydrogenase
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TOP2B topoisomerase (DNA) II beta 180kDa