BRD-K93060291_TL_HRAS24 BRD-K93060291_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K93060291_TL_HRAS24 BRD-K93060291_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL6A2 collagen, type VI, alpha 2
COL7A1 collagen, type VII, alpha 1
CTSF cathepsin F
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
FADS3 fatty acid desaturase 3
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GCH1 GTP cyclohydrolase 1
GCLM glutamate-cysteine ligase, modifier subunit
GPI glucose-6-phosphate isomerase
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ISG20 interferon stimulated exonuclease gene 20kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP3 latent transforming growth factor beta binding protein 3
LTBP4 latent transforming growth factor beta binding protein 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP2 microfibrillar-associated protein 2
MFSD10 major facilitator superfamily domain containing 10
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP1 matrix metallopeptidase 1
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKL phosphofructokinase, liver
PFKP phosphofructokinase, platelet
PRAME preferentially expressed antigen in melanoma
PRSS21 protease, serine, 21 (testisin)
RHOB ras homolog family member B
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
STX1A syntaxin 1A (brain)
STXBP2 syntaxin binding protein 2
TERT telomerase reverse transcriptase
TFF3 trefoil factor 3 (intestinal)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
ANXA1 annexin A1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ATF1 activating transcription factor 1
AURKA aurora kinase A
C3ORF14 chromosome 3 open reading frame 14
CBR3 carbonyl reductase 3
CCNB1 cyclin B1
CCND2 cyclin D2
CCNF cyclin F
CD200 CD200 molecule
CD24 CD24 molecule
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
COG2 component of oligomeric golgi complex 2
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EXOSC4 exosome component 4
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GPX1 glutathione peroxidase 1
GPX7 glutathione peroxidase 7
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H4C histone cluster 1, H4c
INPP5F inositol polyphosphate-5-phosphatase F
KIF20A kinesin family member 20A
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
LPAR6 lysophosphatidic acid receptor 6
MOK MOK protein kinase
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
NOP16 NOP16 nucleolar protein
NPY neuropeptide Y
NRP1 neuropilin 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SEPHS1 selenophosphate synthetase 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SORBS1 sorbin and SH3 domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTSSA serine palmitoyltransferase, small subunit A
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TEX10 testis expressed 10
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM4SF1 transmembrane 4 L six family member 1
TMX4 thioredoxin-related transmembrane protein 4
TRIAP1 TP53 regulated inhibitor of apoptosis 1
ZFP36L2 ZFP36 ring finger protein-like 2