BRD-K93034159_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K93034159_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ARG2 arginase 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CAPG capping protein (actin filament), gelsolin-like
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUOX2 dual oxidase 2
DUSP3 dual specificity phosphatase 3
EPHA2 EPH receptor A2
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FXYD3 FXYD domain containing ion transport regulator 3
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GRN granulin
HBEGF heparin-binding EGF-like growth factor
HEXA hexosaminidase A (alpha polypeptide)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFI27 interferon, alpha-inducible protein 27
INPP1 inositol polyphosphate-1-phosphatase
KRT18 keratin 18, type I
LOXL1 lysyl oxidase-like 1
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAN2B1 mannosidase, alpha, class 2B, member 1
MIR22HG MIR22 host gene
MVP major vault protein
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
OBSL1 obscurin-like 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PLXNB2 plexin B2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYCARD PYD and CARD domain containing
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS27L ribosomal protein S27-like
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SFN stratifin
SOWAHC sosondowah ankyrin repeat domain family member C
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
THBD thrombomodulin
TMEM2 transmembrane protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
WDR45 WD repeat domain 45
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
CCNA2 cyclin A2
DNM1L dynamin 1-like
EIF4B eukaryotic translation initiation factor 4B
EPCAM epithelial cell adhesion molecule
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABPB1 GA binding protein transcription factor, beta subunit 1
HMGB1 high mobility group box 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MYB v-myb avian myeloblastosis viral oncogene homolog
PBK PDZ binding kinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SMAD1 SMAD family member 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF4 transcription factor 4