BRD-K93023739_IKK Inhibitor X_VCAP_6.0_h_6.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K93023739_IKK Inhibitor X_VCAP_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAST calpastatin
CCND2 cyclin D2
CXCL9 chemokine (C-X-C motif) ligand 9
DUSP22 dual specificity phosphatase 22
FN1 fibronectin 1
GPNMB glycoprotein (transmembrane) nmb
IGFBP5 insulin-like growth factor binding protein 5
IL13RA1 interleukin 13 receptor, alpha 1
JAG1 jagged 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MEOX2 mesenchyme homeobox 2
MPPED2 metallophosphoesterase domain containing 2
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
PEG3 paternally expressed 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
SCGB1D2 secretoglobin, family 1D, member 2
SFRP4 secreted frizzled-related protein 4
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52L1 tumor protein D52-like 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
BST2 bone marrow stromal cell antigen 2
CLDN18 claudin 18
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
FLRT3 fibronectin leucine rich transmembrane protein 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGFBP6 insulin-like growth factor binding protein 6
ISG15 ISG15 ubiquitin-like modifier
LBH limb bud and heart development
MX1 MX dynamin-like GTPase 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP18 ubiquitin specific peptidase 18