BRD-K92817986_bjm-csc-19 BRD-K92817986_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K92817986_bjm-csc-19 BRD-K92817986_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
CCL4 chemokine (C-C motif) ligand 4
CCPG1 cell cycle progression 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
DDIT4 DNA-damage-inducible transcript 4
GADD45A growth arrest and DNA-damage-inducible, alpha
HMOX1 heme oxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFRD1 interferon-related developmental regulator 1
IL1B interleukin 1, beta
ITM2A integral membrane protein 2A
KLF5 Kruppel-like factor 5 (intestinal)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCOA3 nuclear receptor coactivator 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
CBR3 carbonyl reductase 3
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CENPE centromere protein E, 312kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FEN1 flap structure-specific endonuclease 1
FPGS folylpolyglutamate synthase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MMP11 matrix metallopeptidase 11
NCAPH non-SMC condensin I complex, subunit H
NKX3-1 NK3 homeobox 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
OAT ornithine aminotransferase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RAI14 retinoic acid induced 14
RFC2 replication factor C (activator 1) 2, 40kDa
SERHL2 serine hydrolase-like 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
ZW10 zw10 kinetochore protein