BRD-K92571446_WZ-3105_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K92571446_WZ-3105_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BEX1 brain expressed, X-linked 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CAPN1 calpain 1, (mu/I) large subunit
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHEK2 checkpoint kinase 2
CHRDL1 chordin-like 1
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP1 dual specificity phosphatase 1
EIF1 eukaryotic translation initiation factor 1
EPHA3 EPH receptor A3
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
H2BFS H2B histone family, member S (pseudogene)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IER3 immediate early response 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTA4H leukotriene A4 hydrolase
MAOA monoamine oxidase A
MAOB monoamine oxidase B
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MSLN mesothelin
MSN moesin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMU neuromedin U
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDIA3 protein disulfide isomerase family A, member 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP2 syntaxin binding protein 2
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TSC22D1 TSC22 domain family, member 1
TUSC3 tumor suppressor candidate 3
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
CANT1 calcium activated nucleotidase 1
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHD7 chromodomain helicase DNA binding protein 7
CHIC2 cysteine-rich hydrophobic domain 2
CSNK1D casein kinase 1, delta
CXCL13 chemokine (C-X-C motif) ligand 13
DCLRE1C DNA cross-link repair 1C
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GTPBP4 GTP binding protein 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA14 heat shock 70kDa protein 14
IER5 immediate early response 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL2RB interleukin 2 receptor, beta
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KDM3A lysine (K)-specific demethylase 3A
KYNU kynureninase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAGL2 pleiomorphic adenoma gene-like 2
POGK pogo transposable element with KRAB domain
PPIF peptidylprolyl isomerase F
RPP38 ribonuclease P/MRP 38kDa subunit
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SCAF8 SR-related CTD-associated factor 8
SETD5 SET domain containing 5
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPATA2 spermatogenesis associated 2
TBPL1 TBP-like 1
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D2 TSC22 domain family, member 2
WAC WW domain containing adaptor with coiled-coil
WDR37 WD repeat domain 37
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217