BRD-K92571446_WZ-3105_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K92571446_WZ-3105_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
CA4 carbonic anhydrase IV
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CKB creatine kinase, brain
CLU clusterin
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
DLK1 delta-like 1 homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM107A family with sequence similarity 107, member A
FAS Fas cell surface death receptor
FLRT3 fibronectin leucine rich transmembrane protein 3
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GSTT1 glutathione S-transferase theta 1
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HOPX HOP homeobox
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ITM2A integral membrane protein 2A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF10 Kruppel-like factor 10
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LYZ lysozyme
MAL mal, T-cell differentiation protein
MYLK myosin light chain kinase
NEFL neurofilament, light polypeptide
NLGN4X neuroligin 4, X-linked
NSG1 neuron specific gene family member 1
PCP4 Purkinje cell protein 4
PDZK1 PDZ domain containing 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RUFY3 RUN and FYVE domain containing 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFTPB surfactant protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNX11 sorting nexin 11
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TFPI2 tissue factor pathway inhibitor 2
TOB1 transducer of ERBB2, 1
TUSC3 tumor suppressor candidate 3
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
ZFP36 ZFP36 ring finger protein
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
CCNF cyclin F
CHD7 chromodomain helicase DNA binding protein 7
CHIC2 cysteine-rich hydrophobic domain 2
COL5A1 collagen, type V, alpha 1
CSNK1D casein kinase 1, delta
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF5A eukaryotic translation initiation factor 5A
GABPB1 GA binding protein transcription factor, beta subunit 1
IFI16 interferon, gamma-inducible protein 16
IFI6 interferon, alpha-inducible protein 6
IRS2 insulin receptor substrate 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NUP62 nucleoporin 62kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
ZDHHC6 zinc finger, DHHC-type containing 6