BRD-K92571446_WZ-3105_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

259 genes differentially expressed following the BRD-K92571446_WZ-3105_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHSG alpha-2-HS-glycoprotein
AIF1 allograft inflammatory factor 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA4 annexin A4
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BLNK B-cell linker
BPIFA1 BPI fold containing family A, member 1
BSG basigin (Ok blood group)
C7 complement component 7
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CD209 CD209 molecule
CD52 CD52 molecule
CD69 CD69 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CFB complement factor B
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC4A C-type lectin domain family 4, member A
CLEC7A C-type lectin domain family 7, member A
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
COLEC11 collectin sub-family member 11
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
FPR3 formyl peptide receptor 3
FRZB frizzled-related protein
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSN gelsolin
HBE1 hemoglobin, epsilon 1
HCAR3 hydroxycarboxylic acid receptor 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN4 high mobility group nucleosomal binding domain 4
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
ITGB7 integrin, beta 7
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT8 keratin 8, type II
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LITAF lipopolysaccharide-induced TNF factor
LTB lymphotoxin beta (TNF superfamily, member 3)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
METRN meteorin, glial cell differentiation regulator
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5DC2 5'-nucleotidase domain containing 2
NTS neurotensin
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PARM1 prostate androgen-regulated mucin-like protein 1
PBX3 pre-B-cell leukemia homeobox 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG3 paternally expressed 3
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PTPRC protein tyrosine phosphatase, receptor type, C
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RAB31 RAB31, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RNF130 ring finger protein 130
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCG5 secretogranin V
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SIK1 salt-inducible kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMYD3 SET and MYND domain containing 3
SORT1 sortilin 1
SPP1 secreted phosphoprotein 1
STAB1 stabilin 1
STAR steroidogenic acute regulatory protein
SULF1 sulfatase 1
TBX2 T-box 2
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPGS2 tubulin polyglutamylase complex subunit 2
TPM4 tropomyosin 4
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
AKAP1 A kinase (PRKA) anchor protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BLMH bleomycin hydrolase
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
ITGA6 integrin, alpha 6
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KRT10 keratin 10, type I
LBR lamin B receptor
MAPK6 mitogen-activated protein kinase 6
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MRPS30 mitochondrial ribosomal protein S30
MYBPC1 myosin binding protein C, slow type
NCOA6 nuclear receptor coactivator 6
NMI N-myc (and STAT) interactor
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
NSFL1C NSFL1 (p97) cofactor (p47)
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PIP prolactin-induced protein
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PROM1 prominin 1
RAB4A RAB4A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RPL36AL ribosomal protein L36a-like
SCEL sciellin
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNX11 sorting nexin 11
SPRR1A small proline-rich protein 1A
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TJP2 tight junction protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAPPC3 trafficking protein particle complex 3
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UBAP2 ubiquitin associated protein 2
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)
ZNF22 zinc finger protein 22